HORDB

ID: hor002685
Uniprot ID: Q19569
Protein name: NLP-7
Gene name: nlp-7
Organism: Caenorhabditis elegans
Family: NA
Source: animal
Expression: Up-regulated when diet is restricted.
Disease: NA
Comments: NA
Taxonomy: Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0008340 determination of adult lifespan; GO:0061771 response to caloric restriction; GO:1901046 positive regulation of egg-laying behavior; GO:1901562 response to paraquat
GO CC: NA

Sequence: MILPSLADLHRYTMYD
Length: 16(84-99)
Propeptide: MYIKAALLIVVLFGVASQITSALYLKQADFDDPRMFTSSFGKRSAIESEPQAYPKSYRAIRIQRRSMDDLDDPRLMTMSFGKRMILPSLADLHRYTMYDKRGSDIDDPRYFLFSNRLTCRC
Signal peptide: MYIKAALLIVVLFGVASQITSA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: May regulate lifespan in response to food availability and oxidative stress.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002685_AF2.pdb

hor002685_ESM.pdb

Mass:	220702	Formula:	C87H135N21O25S2
Absent amino acids:	CEFGKNQVW	Common amino acids:	L
pI:	5.41	Basic residues:	2
Polar residues:	4	Hydrophobic residues:	5
Hydrophobicity:	6.88	Boman Index:	-1708
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	103.75
Instability Index:	5976.25	Extinction Coefficient cystines:	2980
Absorbance 280nm:	198.67

PubMed ID: 20013198
Title: Approaches to Identify Endogenous Peptides in the Soil Nematode Caenorhabditis elegans